trying to upload sketch Atmega328 8Mhz internal clock

Hi,
I'm using an atmega328p in standalone mode with 8Mhz internal clock.
I can burn the bootloader and sketch thorugh the isp interface but i can't upload sketch with a usb-to-ttl (tx and rx).

On pin reset i use 100nF capacitor and 10k pullup resistor.
When i upload sketch the ide starts but never end.

Do you know if is there some reason becouse the UART doesn't work in this case?

Thanks.